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Product Details
MA5-35721
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Recombinant Monoclonal |
Type |
Antibody |
Clone |
ARC1312 |
Immunogen |
A recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human VAMP3. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2849621 |
Target Information
Synaptobrevins/VAMPs, syntaxins, and the 25-kDa synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CEB; Cellubrevin; Synaptobrevin-3; vamp; VAMP-3; Vesicle-associated membrane protein 3
Gene Aliases: CEB; D130027G05Rik; SYB3; VAMP-3; VAMP3
UniProt ID: (Human) Q15836, (Mouse) P63024
Entrez Gene ID: (Human) 9341, (Mouse) 22319
positive regulation of receptor recycling
protein complex assembly
transport
vesicle fusion
protein transport
vesicle-mediated transport
calcium ion regulated exocytosis
substrate adhesion-dependent cell spreading
SNARE complex assembly
retrograde transport, endosome to Golgi
Golgi to plasma membrane protein transport
negative regulation of secretion by cell
exocytosis
vesicle docking involved in exocytosis
positive regulation of immunoglobulin secretion
membrane fusion
mucus secretion
regulation of histamine secretion by mast cell
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