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|Tested species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a, Kappa|
|Immunogen||Mouse preadipose cell line PA6|
|Storage buffer||50mM sodium borate|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:10-1:1000|
|Immunohistochemistry (Frozen) (IHC (F))||1:10-1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Suggested positive control: bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells.
CD106 is a 110 kD glycosylphosphatidylinositol (GPI)-linked transmembrane protein, also known as VCAM-1 and INCAM-110. It is constitutively expressed on bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells, as well as some lymphocytes. CD106 expression can be upregulated on endothelial cells by inflammatory cytokines. CD106 is involved in adhesion and acts as a counter-receptor for VLA-4 ( alpha4/ beta1 integrin) and LPAM-1 ( alpha4/ beta7 integrin). The 429 antibody has been reported to partially block VCAM-1-mediated binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD106; V-CAM 1; vascular cell adhesion protein 1; Vcam-1