This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants.
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Protein Aliases: B36-VDAC; FLJ23841; Outer mitochondrial membrane protein porin 2; RP11-375G3.1; VDAC-2; VDAC-6; voltage-dependent anion channel 2; Voltage-dependent anion-selective channel protein 2; Voltage-dependent anion-selective channel protein 6
Gene Aliases: mVDAC2; mVDAC6; POR; VDAC2; Vdac6
Molecular Function: voltage-gated ion channel