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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the C-terminal sequence of propeptide form of VEGF-C.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (Paraffin, Frozen) (IHC (P, F))||See 2 publications below|
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Intratumoral lymphatic vessels and VEGF-C expression are predictive factors of lymph node relapse in T1-T4 N0 laryngopharyngeal squamous cell carcinoma.
||Hinojar-Gutiérrez A,Fernández-Contreras ME,González-González R,Fernández-Luque MJ,Hinojar-Arzadún A,Quintanilla M,Gamallo C||Annals of surgical oncology (14:248)||2007|
Aberrant expression of VEGF-C is related to grade of cervical intraepithelial neoplasia (CIN) and high risk HPV, but does not predict virus clearance after treatment of CIN or prognosis of cervical cancer.
||Branca M,Giorgi C,Santini D,Di Bonito L,Ciotti M,Benedetto A,Paba P,Costa S,Bonifacio D,Di Bonito P,Accardi L,Favalli C,Syrjänen K||Journal of clinical pathology (59:40)||2006|
FLT4 ligand DHM, VEGF-C, vascular endothelial growth factor C, vascular endothelial growth factor-related protein, Flt4-L, VRP