MA1-24888 detects VEGF Receptor 2 from human samples.
MA1-24888 has been successfully used in immunohistochemistry, ELISA and Western blot procedures. The predicted molecular weight is 152 kDa.
The MA1-24888 immunogen is recombinant, extracellular fragment of human VEGF2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
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Protein Aliases: 6130401C07; CD309; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; Flk1; KDR; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Krd-1; Ly73; Protein-tyrosine kinase receptor flk-1; soluble VEGFR2; sVEGFR-2; tyrosine kinase growth factor receptor; Vascular endothelial growth factor receptor 2; VEGFR-2; VEGFR2
Gene Aliases: CD309; FLK1; KDR; VEGFR; VEGFR2
UniProt ID: (Human) P35968
Entrez Gene ID: (Human) 3791