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Product Details
MA5-42739
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
8L3D8
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human VPS11 (Q9H270).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.84 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2911880
Product Specific Information
Positive test controls include: HeLa, A-431, Raji, Mouse testis, Mouse brain.
Target Information
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hVPS11; RING finger protein 108; vacuolar protein sorting 11 homolog; Vacuolar protein sorting-associated protein 11 homolog; VPS11 CORVET/HOPS core subunit
Gene Aliases: 1200011A11Rik; END1; HLD12; hVPS11; PEP5; PP3476; RNF108; VPS11
UniProt ID: (Human) Q9H270, (Mouse) Q91W86
Entrez Gene ID: (Human) 55823, (Mouse) 71732
Molecular Function:
membrane trafficking regulatory protein
intracellular protein transport
vesicle docking involved in exocytosis
autophagy
endosome organization
lysosome organization
endosome to lysosome transport
regulation of protein stability
endosomal vesicle fusion
regulation of SNARE complex assembly
regulation of organelle assembly
positive regulation of cellular protein catabolic process
positive regulation of protein targeting to mitochondrion
positive regulation of early endosome to late endosome transport
transport
protein transport
vesicle-mediated transport
toxin transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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