CTXL, a cortical thymocyte marker, is a member of the immunoglobulin (Ig) superfamily and has features of both antigen specific receptors and adhesion molecules. This single pass, type I protein contains a signal peptide, an extracellular V type Ig like domain followed by a C2 type Ig like domain and a cytoplasmic tail. Expression levels of CTXL are high in the stomach, colon, prostate, trachea, and thyroid gland, with lower levels observed in bladder and lung tissues. CTXL is not expressed in the thymus. CTXL is developmentally regulated and may be involved in thymocyte selection. It localizes to junctional complexes between endothelial and epithelial cells and may play a role in cell-cell adhesion and transmigration of leukocytes.
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