Von Willebrand factor (vWf) is a series of self-aggregated structures, all derived from common glycoprotein subunits, synthesized in endothelial cells and megakaryocytes. The molecular mass of the monomeric vWf unit is 225 kDa. vWf binds to circulating factor VIIIc (antihemophilic factor), hereby stabilizing the latter thus being an important factor in the normal primary haemostasis.
Protein Aliases: coagulation factor VIII VWF; factor viii related antigen; von Willebrand antigen 2; von Willebrand antigen II; von Willebrand factor; vWF
Gene Aliases: F8VWF; VWD; VWF
UniProt ID: (Human) P04275
Entrez Gene ID: (Human) 7450
Molecular Function: extracellular matrix protein