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|Tested species reactivity||Human, Mouse, Non-human primate, Rat|
|Published species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||synthetic peptide, RASLDSEESESPPQENSC, corresponding to amino-terminus of Rat VR1, amino acids 4-21.|
|Storage buffer||whole serum|
|Contains||0.05% sodium azide|
|Storage Conditions||-80° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:1000|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-29421 detects Vanilloid receptor 1 from rat, human, mouse, and non-human primate samples.
PA1-29421 has been successfully used in immunocytochemistry, immunohistochemistry (frozen tissue), and Western blot applications. A suggested positive control for this product is VR1 transfected cells. Predicted molecular weight of approximately 100.7 kDa.
The PA1-29421 immunogen is synthetic peptide, RASLDSEESESPPQENSC, corresponding to amino-terminus of Rat VR1, amino acids 4-21.
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Enhanced salt sensitivity following shRNA silencing of neuronal TRPV1 in rat spinal cord.
PA1-29421 was used in western blot to investigate the role of neuronal TRPV1 in salt sensitivity of rats
|Yu SQ,Wang DH||Acta pharmacologica Sinica (32:845)||2011|
Brain-derived neurotrophic factor redistribution in the dorsal root ganglia correlates with neuropathic pain inhibition after resiniferatoxin treatment.
PA1-29421 was used in immunohistochemistry to investigate the influence of BDNF redistribution on neuropathic pain modulation in dorsal root ganglia
|Tender GC,Li YY,Cui JG||The spine journal : official journal of the North American Spine Society (10:715)||2010|
Capsaicin Receptor; cation channel; osm-9-like TRP channel 1; OTRPC1; transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel V1; transient receptor potential cation channel, subfamily V, member 1; transient receptor potential vanilloid 1 supraoptic nucleus; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; Vanilloid receptor; vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; vanilloid type 1 receptor; VR1
OTRPC1; TRPV1; TRPV1_SON; TRPV1alpha; TRPV1beta; VR-1; VR.5'sv; VR1; Vr1l; Vr1l1