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|Tested species reactivity||Rat|
|Published species reactivity||Rat, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to the N-terminal region of rat SLC32A1 conjugated to KLH|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with bovine, canine and non-human primate based on 100% sequence homology.
In Western blot, this antibody is specific for the ~53 kDa VGAT protein.
The Vesicular GABA Amino Acid Transporter (VGAT) is responsible for transport of the inhibitory neurotransmitter into synaptic vesicles(McIntire et al., 1997). The VGAT protein (also known as the Vesicular Inhibitory Amino Aid Transporter or VIAAT) is expressed in synaptic vesicles of both glycine and GABAergic synapses throughout the CNS (Chaudhry et al., 1998). Expression of the VGAT protein changes during development and also in response to patterns of neuronal activity (De et al., 2005).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Cerebellar zonal patterning relies on Purkinje cell neurotransmission.
PA1-4701 was used in immunohistochemistry to investigate the role of Purkinje cell neurotransmission
|White JJ,Arancillo M,Stay TL,George-Jones NA,Levy SL,Heck DH,Sillitoe RV||The Journal of neuroscience : the official journal of the Society for Neuroscience (34:8231)||2014|
Molecular mechanisms supporting a paracrine role of GABA in rat adrenal medullary cells.
PA1-4701 was used in immunocytochemistry to study the paracrine role of GABA in adrenal medullary cells.
|Matsuoka H,Harada K,Endo Y,Warashina A,Doi Y,Nakamura J,Inoue M||The Journal of physiology (586:4825)||2008|
GABA and glycine transporter; GVAT; rGVAT; solute carrier family 32 member 1; vesicular GABA transporter; Vesicular GABA transporterr; vesicular inhibitory amino acid transporter
Slc32a1; Vgat; Viaat