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Immunogen sequence: MTKLSAQVK GSLNITTPGL QIWRIEAMQM VPVPSSTFGS FFDGDCYIIL AIHKTASSLS YDIHYWIGQD SSLDEQGAAA IYTTQMDDFL KGRAVQHREV QGNESEAFRG YFKQGLVIRK GGVASGMKHV ETNSYDVQRL LHVKGKRNVV AGEVEMSWKS FNRGDVFLLD LGKLIIQWNG PESTRMERLR GMTLAKEIRD QERGGRTYVG VVDGENELAS PKLMEVMNHV LGKRRELKAA VPDTVVEPAL KAALKLYHVS DSEGNLVVRE VATRPLTQDL LSHEDCYILD QGGLKIYVWK GKKANEQEKK GAMSHALNFI KAKQYPPSTQ VEVQNDGAES AVFQQLFQKW T (1-350 aa encoded by BC017303)
Villin is part of cytoskeleton associated with the microvillar actin core bundle of gastrointestinal and renal brush border. It can interact with actin in a Ca2+ and phosphoinositide-regulated manner. Villin is a very specific marker for adenocarcinomas of the gastrointestinal tract and the pancreas. It is also expressed in some Merkel cell tumor and adenocarcinoma of the lung, prostate, ovarian and kidney.
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Protein Aliases: OTTHUMP00000207159; Villin-1
Gene Aliases: D2S1471; VIL; VIL1
UniProt ID: (Human) P09327, (Mouse) Q62468
Entrez Gene ID: (Human) 7429, (Mouse) 22349
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