This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.
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Protein Aliases: dJ461P17.6; EDDM4; epididymal protein 4; Epididymal secretory protein E4; epididymis-specific; epididymis-specific, whey-acidic protein type, four-disulfide core; four-disulfide core; HE4; major epididy; Major epididymis-specific protein E4; MGC57529; Putative protease inhibitor WAP5; WAP domain containing protein HE4-V4; WAP four-disulfide core domain 2; WAP four-disulfide core domain protein 2; WAP5; WFDC2; whey-acidic protein type
Gene Aliases: dJ461P17.6; EDDM4; HE4; WAP5; WFDC2
UniProt ID: (Human) Q14508
Entrez Gene ID: (Human) 10406