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Product Details
MA5-17199
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
6B11H8
Immunogen
Purified recombinant fragment of human WHSC2 (amino acids: 280-511) expressed in E. Coli.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2538670
Product Specific Information
MA5-17199 targets WHSC2 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human and Rat samples.
The MA5-17199 immunogen is purified recombinant fragment of human WHSC2 (amino acids: 280-511) expressed in E. Coli.
MA5-17199 detects WHSC2 which has a predicted molecular weight of approximately 57.3kDa.
Target Information
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ10442; FLJ25112; Negative elongation factor A; NELF-A; Wolf-Hirschhorn syndrome candidate 2 protein
Gene Aliases: NELF-A; NELFA; P/OKcl.15; WHSC2
UniProt ID: (Human) Q9H3P2
Entrez Gene ID: (Human) 7469, (Rat) 305455
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
multicellular organism development
negative regulation of transcription elongation from RNA polymerase II promoter
positive regulation of viral transcription
positive regulation of transcription from RNA polymerase II promoter
positive regulation of histone H3-K4 methylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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