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Product Details
WIT-101-BIOTIN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 700-750 on WIT Wishful Thinking D. melanogaster protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Wishful thinking (wit) gene, the Drosophila homolog of the vertebrate BMP type II receptor. Mutations in wit result in pharate lethality that can be rescued by expression of a wit transgene in motor neurons but not in muscles. Mutant larvae exhibit small synapses, severe defects in evoked junctional potentials, a lower frequency of spontaneous vesicle release, and an alteration in the ultrastructure of synaptic active zones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bone morphogenetic protein; CG10776; CG10776-PA; CG10776-PB; GH13548p; Receptor protein serine/threonine kinase; Serine/threonine kinase-D; wit; wit-PA; wit-PB
Gene Aliases: 1262/15; ALK3/BMPRII; BMP; CG10776; Dmel\CG10776; Dmel_CG10776; l(3)64Aa; l(3)S126215; l(3)SH12; SE20; STK-D; WIT; Wit-C; wiw
Entrez Gene ID: (Fruit fly) 44096
protein phosphorylation
neuromuscular synaptic transmission
ventral cord development
neuromuscular junction development
BMP signaling pathway
activin receptor signaling pathway
positive regulation of synaptic growth at neuromuscular junction
dendrite morphogenesis
synaptic growth at neuromuscular junction
SMAD protein signal transduction
cellular response to growth factor stimulus
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