The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: INT4; Proto-oncogene Int-4; Proto-oncogene Int-4 homolog; proto-oncogene protein Wnt-3; Proto-oncogene Wnt-3; wingless-related MMTV integration site 3; Wingless-type MMTV integration site 3, homolog; wingless-type MMTV integration site family member 3; wingless-type MMTV integration site family, member 3; WNT-3 proto-oncogene protein
Gene Aliases: Int-4; INT4; TETAMS; Wnt-3; WNT3
Molecular Function: signaling molecule