Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product # 7KMWCO
WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway. This pathway plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. WWC1, along with NF2, can synergistically induce the phosphorylation of LATS1 and LATS2. It acts as a transcriptional coactivator of ESR1 - which plays an essential role in DYNLL1-mediated ESR1 transactivation. WWC1 also functions as a regulatior of collagen-stimulated activation of the ERK/MAPK cascade.
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Protein Aliases: HBeAg-binding protein 3; HBEBP3; HBEBP36; KIBRA; Kidney and brain protein; MEMRYQTL; PPP1R168; Protein KIBRA; protein phosphatase 1, regulatory subunit 168; protein WWC1; WW domain-containing protein 1; WW, C2 and coiled-coil domain containing 1
Gene Aliases: HBEBP3; HBEBP36; KIAA0869; KIBRA; MEMRYQTL; PPP1R168; WWC1
UniProt ID: (Human) Q8IX03
Entrez Gene ID: (Human) 23286