|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the internal region of human APBA3|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Amyloid beta precursor protein ( beta APP) is a major constituent of the amyloid deposits in patients with Alzheimer's disease. The amyloid beta precursor is known to interact with several proteins, including the G heterotrimetric protein, APP-BP1, and X11. The neuronal, transmembrane protein X11 is known to bind to the amyloid beta precurser protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular beta APP and slowing beta APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of beta APP. Multiple splice varitents of X11 have been identified, including X11 alpha, beta and gamma (also known as Mint 1, 2 and 3, respectively).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.