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Proteintech

XBP1S Recombinant Rabbit Monoclonal Antibody (241004C10)

View all (3) XBP1S antibodies

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Product Details

83959-6-RR

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:800
-

ELISA (ELISA)

Assay-dependent
-

Surface plasmon resonance (SPR)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

241004C10

Immunogen

XBP1S-specific fusion protein Ag21703 (167-376).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: GAGPVVTPPE HLPMDSGGID SSDSESDILL GILDNLDPVM FFKCPSPEPA SLEELPEVYP EGPSSLPASL SLSVGTSSAK LEAINELIRF DHIYTKPLVL EIPSETESQA NVVVKIEEAP LSPSENDHPE FIVSVKEEPV EDDLVPELGI SNLLSSSHCP KPSSCLLDAY SDCGYGGSLS PFSDMSSLLG VNHSWEDTFA NELFPQLISV

Target Information

X-box binding protein 1, spliced form (XBP1S), is a critical transcription factor involved in the unfolded protein response (UPR). Located on chromosome 22q12, XBP1S is derived from the unspliced XBP1 mRNA through a unique splicing event mediated by the endoribonuclease IRE1 alpha under endoplasmic reticulum (ER) stress conditions. Structurally, XBP1S belongs to the cAMP-response element-binding (CREB)/activating transcription factor (ATF) family and contains a basic-region leucine zipper (bZIP) domain that enables its function as a transcription factor. Functionally, XBP1S migrates to the nucleus where it regulates a broad range of genes involved in ER-associated degradation (ERAD), lipid biosynthesis, and molecular chaperones, aimed at restoring homeostasis and decreasing ER stress. Additionally, the IRE1 alpha-XBP1S signaling pathway has been implicated in cancer cell proliferation and various diseases characterized by misfolded protein accumulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: tax-responsive element-binding protein 5; unnamed protein product; X box binding protein-1; XBP1

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Gene Aliases: TREB-5; TREB5; XBP-1; XBP2

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UniProt ID: (Human) P17861

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Entrez Gene ID: (Human) 7494

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding protease binding transcription factor activity, sequence-specific DNA binding protein binding protein kinase binding estrogen receptor binding chromatin DNA binding ubiquitin protein ligase binding identical protein binding histone deacetylase binding sequence-specific DNA binding ubiquitin-like protein ligase binding protein heterodimerization activity sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis regulation of cell growth liver development positive regulation of protein phosphorylation endothelial cell proliferation positive regulation of immunoglobulin production regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter ubiquitin-dependent protein catabolic process fatty acid biosynthetic process immune response positive regulation of cell proliferation positive regulation of autophagy negative regulation of myotube differentiation positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway endoplasmic reticulum unfolded protein response regulation of protein stability protein destabilization cellular response to nutrient positive regulation of TOR signaling positive regulation of interleukin-6 production cellular response to insulin stimulus cellular response to oxidative stress response to endoplasmic reticulum stress cellular triglyceride homeostasis positive regulation of vascular wound healing cellular response to vascular endothelial growth factor stimulus IRE1-mediated unfolded protein response ATF6-mediated unfolded protein response ERAD pathway cellular response to glucose starvation positive regulation of protein import into nucleus cholesterol homeostasis negative regulation of apoptotic process protein kinase B signaling positive regulation of MHC class II biosynthetic process positive regulation of B cell differentiation positive regulation of T cell differentiation positive regulation of fat cell differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter vascular endothelial growth factor receptor signaling pathway neuron development positive regulation of protein kinase B signaling fatty acid homeostasis sterol homeostasis negative regulation of SMAD protein import into nucleus adipose tissue development negative regulation of ERK1 and ERK2 cascade positive regulation of phospholipid biosynthetic process cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to fructose stimulus cellular response to glucose stimulus cellular response to interleukin-4 cellular response to peptide hormone stimulus cellular response to fluid shear stress cellular response to laminar fluid shear stress positive regulation of cytokine production involved in inflammatory response positive regulation of plasma cell differentiation negative regulation of endoplasmic reticulum unfolded protein response positive regulation of protein acetylation negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of lactation positive regulation of ERAD pathway positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration response to insulin-like growth factor stimulus positive regulation of hepatocyte proliferation positive regulation of endothelial cell apoptotic process
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