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XBP1S/XBP1U Polyclonal Antibody, CoraLite® Plus 488

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XBP1S/XBP1U Polyclonal Antibody, CoraLite® Plus 488

Product Details

CL488-24168

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

0.80 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

XBP1S/XBP1U fusion protein Ag21454
3D Epitope / Immunogen

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MVVVAAAPN PADGTPKVLL LSGQPASAAG APAGQALPLM VPAQRGASPE AASGGLPQAR KRQRLTHLSP EEKALRRKLK NRVAAQTARD RKKARMSELE QQVVDLEEEN QKLLLENQLL REKTHGLVVE NQELRQRLGM DALVAEEEAE AKGNEVRPVA GSAESAAL

Target Information

XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: OTTHUMP00000028682; tax-responsive element-binding protein 5; tax-responsive element-binding protein 5 homolog; unnamed protein product; X box binding protein-1; XBP-1; transcription factor; XBP1

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Gene Aliases: D11Ertd39e; TREB-5; TREB5; XBP-1; XBP2

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UniProt ID: (Human) P17861, (Mouse) O35426

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Entrez Gene ID: (Human) 7494, (Mouse) 22433

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding protease binding transcription factor activity, sequence-specific DNA binding protein binding protein kinase binding estrogen receptor binding chromatin DNA binding ubiquitin protein ligase binding identical protein binding histone deacetylase binding sequence-specific DNA binding ubiquitin-like protein ligase binding protein heterodimerization activity sequence-specific double-stranded DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding phosphatidylinositol 3-kinase regulatory subunit binding RNA polymerase II sequence-specific DNA binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis regulation of cell growth liver development positive regulation of protein phosphorylation endothelial cell proliferation epithelial cell maturation positive regulation of immunoglobulin production regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter ubiquitin-dependent protein catabolic process response to nutrient positive regulation of cell proliferation response to xenobiotic stimulus regulation of autophagy positive regulation of autophagy negative regulation of myotube differentiation positive regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway endoplasmic reticulum unfolded protein response exocrine pancreas development regulation of protein stability protein destabilization cellular response to nutrient positive regulation of TOR signaling positive regulation of interleukin-6 production cellular response to insulin stimulus cellular response to oxidative stress response to endoplasmic reticulum stress cellular triglyceride homeostasis positive regulation of vascular wound healing cellular response to vascular endothelial growth factor stimulus IRE1-mediated unfolded protein response cellular response to glucose starvation positive regulation of protein import into nucleus glucose homeostasis cholesterol homeostasis negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process protein kinase B signaling positive regulation of MHC class II biosynthetic process positive regulation of B cell differentiation positive regulation of T cell differentiation positive regulation of fat cell differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter vascular endothelial growth factor receptor signaling pathway neuron development response to electrical stimulus positive regulation of protein kinase B signaling fatty acid homeostasis sterol homeostasis serotonin secretion, neurotransmission negative regulation of SMAD protein import into nucleus adipose tissue development epithelial cell maturation involved in salivary gland development intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress negative regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to fructose stimulus cellular response to glucose stimulus cellular response to interleukin-4 cellular response to peptide hormone stimulus cellular response to fluid shear stress cellular response to laminar fluid shear stress positive regulation of cytokine production involved in inflammatory response positive regulation of plasma cell differentiation negative regulation of endoplasmic reticulum unfolded protein response positive regulation of proteasomal protein catabolic process positive regulation of protein acetylation negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of lactation positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration response to insulin-like growth factor stimulus cellular response to leukemia inhibitory factor positive regulation of hepatocyte proliferation positive regulation of endothelial cell apoptotic process fatty acid biosynthetic process immune response ATF6-mediated unfolded protein response ERAD pathway positive regulation of phospholipid biosynthetic process positive regulation of ERAD pathway
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