Proteintech

XBP1S/XBP1U Polyclonal Antibody, CoraLite® Plus 488

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

CL488-24168

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

0.80 µg/10^6 cells in a 100 µL suspension
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Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

XBP1S/XBP1U fusion protein Ag21454
View immunogen

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MVVVAAAPN PADGTPKVLL LSGQPASAAG APAGQALPLM VPAQRGASPE AASGGLPQAR KRQRLTHLSP EEKALRRKLK NRVAAQTARD RKKARMSELE QQVVDLEEEN QKLLLENQLL REKTHGLVVE NQELRQRLGM DALVAEEEAE AKGNEVRPVA GSAESAAL

Target Information

The X-box binding protein 1 (XBP1) gene, located on chromosome 22q12.1, codes for a critical transcription factor involved in the unfolded protein response (UPR). The gene encodes two protein isoforms: XBP1u (unspliced) and XBP1s (spliced). Under conditions of endoplasmic reticulum (ER) stress, IRE1 alpha senses the misfolded proteins and mediates the unconventional splicing of XBP1 mRNA, converting XBP1u to its active form, XBP1s. The protein product of XBP1s comprises a basic-region leucine zipper (bZIP) domain, essential for its function as a transcription factor. XBP1s regulates the expression of various genes involved in protein folding, secretion, and degradation, thus maintaining cellular homeostasis. It also plays pivotal roles in immune responses, lipid metabolism, and has been implicated in several diseases, including cancer and neurodegenerative disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Tax-responsive element-binding protein 5; tax-responsive element-binding protein 5 homolog; TREB-5; X-box-binding protein 1; XBP-1

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Gene Aliases: D11Ertd39e; TREB-5; TREB5; XBP-1; XBP1; XBP2

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UniProt ID: (Human) P17861, (Mouse) O35426

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Entrez Gene ID: (Human) 7494, (Mouse) 22433

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Function(s)
RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter binding RNA polymerase II transcription factor binding enhancer sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding phosphatidylinositol 3-kinase regulatory subunit binding histone deacetylase binding protein heterodimerization activity RNA polymerase II regulatory region sequence-specific DNA binding protease binding protein kinase binding chromatin DNA binding ubiquitin protein ligase binding sequence-specific DNA binding transcription regulatory region DNA binding
Process(es)
angiogenesis liver development endothelial cell proliferation positive regulation of immunoglobulin production transcription from RNA polymerase II promoter ubiquitin-dependent protein catabolic process fatty acid biosynthetic process autophagy immune response positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response muscle organ development regulation of autophagy negative regulation of myotube differentiation protein transport endoplasmic reticulum unfolded protein response exocrine pancreas development protein destabilization cellular response to nutrient cellular response to insulin stimulus cellular triglyceride homeostasis IRE1-mediated unfolded protein response ATF6-mediated unfolded protein response cellular response to glucose starvation cholesterol homeostasis negative regulation of apoptotic process positive regulation of MHC class II biosynthetic process positive regulation of B cell differentiation positive regulation of T cell differentiation positive regulation of fat cell differentiation positive regulation of transcription from RNA polymerase II promoter neuron development positive regulation of immunoglobulin secretion fatty acid homeostasis sterol homeostasis adipose tissue development epithelial cell maturation involved in salivary gland development intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to fructose stimulus cellular response to glucose stimulus cellular response to interleukin-4 cellular response to peptide hormone stimulus positive regulation of plasma cell differentiation positive regulation of endoplasmic reticulum unfolded protein response positive regulation of proteasomal protein catabolic process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of lactation response to insulin-like growth factor stimulus positive regulation of hepatocyte proliferation positive regulation of interleukin-6 secretion negative regulation of transcription from RNA polymerase II promoter positive regulation of protein phosphorylation epithelial cell maturation transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter lipid metabolic process transport apoptotic process response to unfolded protein multicellular organism development positive regulation of autophagy phosphatidylinositol 3-kinase signaling cell growth cell differentiation positive regulation of histone methylation regulation of protein stability positive regulation of TOR signaling cellular response to oxidative stress response to endoplasmic reticulum stress cellular response to vascular endothelial growth factor stimulus response to drug glucose homeostasis positive regulation of transcription factor import into nucleus vascular endothelial growth factor receptor signaling pathway response to electrical stimulus serotonin secretion, neurotransmission cellular response to fluid shear stress cellular response to laminar fluid shear stress negative regulation of endoplasmic reticulum unfolded protein response positive regulation of protein acetylation positive regulation of endothelial cell apoptotic process
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