Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.
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Protein Aliases: Cernunnos; FLJ12610; NHEJ1; Non-homologous end-joining factor 1; nonhomologous end-joining factor 1; Protein cernunnos; XLF; XRCC4-like factor
Gene Aliases: NHEJ1; XLF
UniProt ID: (Human) Q9H9Q4