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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant human XPA (Xeroderma Pigmentosum group A) protein|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Dot blot (DB)||Assay dependent|
|ELISA (ELISA)||Assay dependent|
|Immunofluorescence (IF)||Assay dependent|
|Western Blot (WB)||1:1000-1:1500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|ELISA (ELISA)||See 4 publications below|
MA1-21460 detects XPA in human samples.
MA1-21460 has been successfully used in ELISA, Immunofluorescence, dot blot and Western Blot procedures. Positive controls of LS174T, MCF-7 cells or human tonsil suggested. Works on pure and partially purified protein but not on crude cell extract.
The MA1-21460 immunogen is recombinant human XPA (Xeroderma Pigmentosum group A) protein.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze/thaw cycles.
The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting(unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Interleukin-13 mucosal production in Helicobacter pylori-related gastric diseases.
MA1-21460 was used in ELISA to study the mucosal production of interleukin 13 in Helicobacter pylori-related gastric diseases
|Marotti B,Rocco A,De Colibus P,Compare D,de Nucci G,Staibano S,Tatangelo F,Romano M,Nardone G||Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver (40:240)||2008|
Modulation of the infant immune responses by the first pertussis vaccine administrations.
MA1-21460 was used in ELISA to study the interleukin 13 production in infants with different pertussis-tetanus-diphtheria-poliomyelitis vaccines
|Mascart F,Hainaut M,Peltier A,Verscheure V,Levy J,Locht C||Vaccine (25:391)||2007|
Bordetella pertussis infection in 2-month-old infants promotes type 1 T cell responses.
MA1-21460 was used in ELISA to investigate the effect of Bordetella pertussis infection on type 1 T cell responses
|Mascart F,Verscheure V,Malfroot A,Hainaut M,Piérard D,Temerman S,Peltier A,Debrie AS,Levy J,Del Giudice G,Locht C||Journal of immunology (Baltimore, Md. : 1950) (170:1504)||2003|
Adaptive immune responses of patients with asthma to the attachment (G) glycoprotein of respiratory synctial virus.
MA1-21460 was used in ELISA to study the effect of the attachment (G) glycoprotein from respiratory synctial virus on wheezing
|Hancock GE,Scheuer CA,Sierzega R,Pryharski KS,McBride JT,Watelet LF,Tebbey PW,Smith JD||The Journal of infectious diseases (184:1589)||2001|
excision repair-controlling; mutant xeroderma pigmentosum complementation group A; xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A; XP1; XPAC
XP1; XPA; XPAC