This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated. View Details
A suggested positive control for this product is HT29, LS174T, HeLa cells or normal testis.
X-Ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. XRCC1 binds to DNA ligase III through the C-terminal 96 amino acids and to DNA polymerase beta through the N-terminal half. . In testis XRCC1 is expressed at high levels. Cells with a mutation of this gene exhibit decreased single strand break repair and reduced recombination repair. They show increased double strand breaks, and sister chromatid exchange is increased up to 10-fold. The XRCC1 might serve as a scaffold protein during base excision-repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: complementing defective; DNA repair protein XRCC1; repair in Chinese hamster; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1; X-ray-repair
Gene Aliases: RCC; XRCC1
UniProt ID: (Human) P18887
Entrez Gene ID: (Human) 7515