MA5-13412 targets XRCC1 in IHC (P), IP, and WB applications and shows reactivity with Human and Rat samples.
The MA5-13412 immunogen is recombinant human XRCC1 protein.
X-Ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. XRCC1 binds to DNA ligase III through the C-terminal 96 amino acids and to DNA polymerase beta through the N-terminal half. In testis XRCC1 is expressed at high levels. Cells with a mutation of this gene exhibit decreased single strand break repair and reduced recombination repair. They show increased double strand breaks, and sister chromatid exchange is increased up to 10-fold. The XRCC1 might serve as a scaffold protein during base excision-repair.
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Protein Aliases: complementing defective; DNA repair protein XRCC1; repair in Chinese hamster; X-ray repair complementing defective repair in Chinese hamster cells 1; x-ray repair cross-complementing group 1 protein; X-ray repair cross-complementing protein 1; X-ray-repair
Gene Aliases: RCC; Xrcc-1; XRCC1