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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 272 and 520 of Human Xylosyltransferase II|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-29127 targets Xylosyltransferase II in IF and WB applications and shows reactivity with Human samples.
The PA5-29127 immunogen is recombinant fragment corresponding to a region within amino acids 272 and 520 of Human Xylosyltransferase II.
The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase, peptide O-xylosyltransferase 1, protein xylosyltransferase 2, xylosyltransferase II, PXYLT2, XT-II, XT2, xylT-II, xylosyltransferase 2
SOS, XT2, xylT-II, PXYLT2, XT-II