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|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant YAP1 protein expressed in bacteria.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 15% glycerol|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ChIP assay (ChIP)||Assay-Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:200|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunocytochemistry (ICC)||See 1 publications below|
Suggested positive control: brain and kidney lysates, and HEK 293 cell lysate, 293 whole cell lysate, antigen standard for YAP1 (transient overexpression lysate), human kidney protein, human brain protein.
YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. As one of several genes of 1q22 amplicon, YAP was r
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma.
PA1-46189 was used in immunocytochemistry, immunohistochemistry - paraffin section, and western blot to discuss the anti-tumor effects of Fbxw7 in HCC and the clinical significance
|Tu K,Yang W,Li C,Zheng X,Lu Z,Guo C,Yao Y,Liu Q||Molecular cancer (13:null)||2014|
65 kDa Yes-associated protein; Protein yorkie homolog; Transcriptional coactivator YAP1; YAP; YAP2; Yes-associated protein 1; yes-associated protein 2; Yes-associated protein YAP65 homolog; yes-associated protein, 65 kDa; YKI; yorkie homolog
AI325207; COB1; YAP; YAP1; YAP2; YAP65; YKI; Yorkie