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|Tested species reactivity||Human , Mouse|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Synthetic peptide derived from the region between the second SH2 domain and the kinase domain of human ZAP-70|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 3 publications below|
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Methodological comparison of two anti-ZAP-70 antibodies.
37-6500 was used in flow cytometry to discuss variance in the detection of ZAP-70 expression by clinical laboratories.
|Degheidy HA,Venzon DJ,Farooqui MZ,Abbasi F,Arthur DC,Wilson WH,Wiestner A,Stetler-Stevenson MA,Marti GE||Cytometry. Part B, Clinical cytometry (80:300)||2011|
Prospective study of clinical and biological prognostic factors at diagnosis in patients with early stage B-cell chronic lymphocytic leukemia.
37-6500 was used in flow cytometry to identify prognostic factors for chronic lymphocytic leukemia using a retrospective series.
|Oliveira AC,de la Banda E,Domingo-Domenech E,Encuentra M,Mercadal S,Domingo A,Alonso E,Espinet B,Grau J,De Sevilla AF,Gonzalez-Barca E||Leukemia & lymphoma (52:429)||2011|
Comparison of methods for determining zeta-chain associated protein - 70 (ZAP-70) expression in patients with B-cell chronic lymphocytic leukemia (B-CLL).
37-6500 was used in flow cytometry to investigate novel monoclonal antibodies to ZAP-70 to detect B-cell chronic lymphocytic leukemia
|Bojarska-Junak A,Giannopoulos K,Kowal M,Dmoszyńska A,Roliński J||Cytometry. Part B, Clinical cytometry (70:293)||2006|
70 kDa zeta-associated protein, 70 kDa zeta-chain associated protein, syk-related tyrosine kinase, zeta chain of T cell receptor associated protein kinase 70kDa, zeta-chain (TCR) associated protein kinase 70kDa, zeta-chain associated protein kinase, 70kD, tyrosine-protein kinase ZAP-70, EC 188.8.131.52, SRK, ZA70, ZAP-70, ZAP70, kinase ZAP70
ZAP-70, STD, STCD, TZK, mur, IMD48, SRK, Srk, mrtle, ADMIO2
Protein metabolism and modification Protein modification Protein phosphorylation Signal transduction Intracellular signaling cascade Immunity and defense Other immune and defense Developmental processes Embryogenesis Cell proliferation and differentiation