Immunogen sequence: STLTHPQRR IDTLNSDGYT PEPARITSPD KPRPMPMDTS VYESPYSDPE ELKDKKLFLK RDNLLIADIE LGCGNFGSVR QGVYRMRKKQ IDVAIKVLKQ GTEKADTEEM MREAQIMHQL DNPYIVRLIG VCQAEALMLV MEMAGGGPLH KFLVGKREEI PVSNVAELLH QVSMGMKYLE EKNFVHRDLA ARNVLLVNRH YAKISDFGLS KALGADDSYY TARSAGKWPL KWYAPECINF RKFSSRSDVW SYGVTMWEAL SYGQKPYKKM KGPEVMAFIE QGKRMECPPE CPPELYALMS DCWIYKWEDR PDFLTVEQRM RACYYSLASK VEGPPGSTQK AEAACA (149-493 aa encoded by BC039039)
ZAP70, a 70 kDa member of the Syk tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.
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Protein Aliases: 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; EC 220.127.116.11; FLJ17670; FLJ17679; kinase ZAP70; Selective T cell defect; Syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70; Tyrosine-protein kinase ZAP-70;TZK; ZA70; Zeta chain associated protein kinase 70kDa; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Gene Aliases: ADMIO2; IMD48; mrtle; mur; SRK; STCD; STD; TZK; ZAP-70; ZAP70