OriGene

ZC3H8 Monoclonal Antibody (OTI9F11), TrueMAB™

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ZC3H8 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-ZC3H8 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA808290)(1:150)

Product Details

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:150

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI9F11

Immunogen

Full length human recombinant protein of human ZC3H8 produced in E.coli.

Conjugate

Unconjugated

Form

liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Target Information

Zinc-finger CCCH domain-containing protein 8 (ZC3H8) acts as a transcriptional repressor of the GATA3 promoter. It is a sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. ZC3H8 induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Zinc finger CCCH domain-containing protein 8; zinc finger CCCH type domain containing 8; zinc finger CCCH-type domain containing 8

Gene Aliases: Fliz1; ZC3H8; ZC3HDC8

UniProt ID: (Human) Q8N5P1

Entrez Gene ID: (Human) 84524

Function(s)

negative regulation of transcription from RNA polymerase II promoter apoptotic process negative regulation of T cell differentiation in thymus snRNA transcription from RNA polymerase II promoter snRNA transcription from RNA polymerase III promoter T cell homeostasis negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase III promoter response to antibiotic positive regulation of thymocyte apoptotic process

Process(es)

RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding poly(A) RNA binding metal ion binding