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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||An 18 amino acid peptide near the amino terminus of human ZHANGFEI.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||10 ug/ml|
|Western Blot (WB)||1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is K562 cell lysate.
PA5-21106 can be used with blocking peptide PEP-1220.
ZHANGFEI, also known as ZF, is a basic region-leucine zipper transcriptional factor that has been implicated in herpes virus infection cycle and related cellular processes. ZHANGFEI protein has a negatively charged active N-terminus, a leucine zipper of six heptad leucine repeats separated by a conserved six amino acid spacer, a basic domain and a bZIP region. ZHANGFEI strongly activates transcription and suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1 dependent manner. It also suppresses the HCFC1 dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CREB/ATF bZIP transcription factor; HCF-binding transcription factor Zhangfei; host cell factor-binding transcription factor Zhangfei; SHP-interacting leucine zipper protein; SMILE, ZF; tyrosine kinase-associated leucine zipper protein LAZip; tyrosine kinase-associated leucine zipper protein LAZipII; Zhangfei
1110034C16Rik; 6330417B10Rik; CREBZF; LAZip; LAZipII; SMILE; ZF