Excitation: 405 nm; Emission: 645 nm; Laser: Blue Laser
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
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Protein Aliases: DAP kinase 3; DAP-like kinase; Death-associated protein kinase 3; Dlk; MYPT1 kinase; ZIP-kinase; ZIPK; Zipper-interacting protein kinase
Gene Aliases: DAPK3; DLK; ZIP; ZIPK
UniProt ID: (Human) O43293
Entrez Gene ID: (Human) 1613
Molecular Function: non-receptor serine/threonine protein kinase