Peptide Sequence: IAAEICPHPP TDLVAFNLQD PQHDSPAPEA SALSQEENPR NQLMALMLLT AQPQELVMFE EVSVCFTSEE WACLGPIQRA LYWDVMLENY GNVTSLGYRK YRRQRNK
ZNF197 product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. ZNF197 is located in a cluster of zinc finger genes at 3p21. Two alternatively spliced transcripts encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: pVHL-associated KRAB domain-containing protein; VHL-associated KRAB-A domain-containing protein; zinc finger protein 166; Zinc finger protein 197; zinc finger protein 20; Zinc finger protein with KRAB and SCAN domains 9; ZnF20
Gene Aliases: D3S1363E; P18; VHLaK; ZKSCAN9; ZNF166; ZNF197; ZNF20; ZSCAN41
UniProt ID: (Human) O14709
Entrez Gene ID: (Human) 10168
Molecular Function: C2H2 zinc finger transcription factor