Immunogen sequence: RPSAFDVGYT LVHLAIRFQR QDMLAILLTE VSQQAAKCIP AMVCPELTEQ IRREIAASLH QRKGDFACYF LTDLVTFTLP ADIEDLP
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
ZRANB1 is a positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. It acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription and may also modulate TNF-alpha signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp762P2216; hTrabid; TRAF-binding domain-containing protein; TRAF-binding protein domain; Ubiquitin thioesterase ZRANB1; Zinc finger Ran-binding domain-containing protein 1; zinc finger, RAN-binding domain containing 1
Gene Aliases: TRABID; ZRANB1
UniProt ID: (Human) Q9UGI0
Entrez Gene ID: (Human) 54764