Engineering a Dual Small Molecule Gated ZAP70 Switch in T Cells.
ACS synthetic biology
Wong NML,Wong WW
MHZAP7020 was used in Flow cytometry/Cell sorting to develop a dual small molecule-gated ZAP70 signalling switch for the regulation of T cell activity.
Fri Apr 20 00:00:00 EDT 2018
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.
The Journal of experimental medicine
Chan AY,Punwani D,Kadlecek TA,Cowan MJ,Olson JL,Mathes EF,Sunderam U,Fu SM,Srinivasan R,Kuriyan J,Brenner SE,Weiss A,Puck JM
MHZAP7020 was used in flow cytometry to identify and characterize human ZAP-70 mutations associated with autoimmune disease
Mon Feb 08 00:00:00 EST 2016
Combined normal donor and CLL: Single tube ZAP-70 analysis.
Cytometry. Part B, Clinical cytometry
Degheidy HA,Venzon DJ,Farooqui MZ,Abbasi F,Arthur DC,Wilson WH,Wiestner A,Stetler-Stevenson MA,Marti GE
MHZAP7020 was used in Flow cytometry/Cell sorting to develop a combined one-tube technology to optimise Zeta-chain-associated protein kinase 70 identification as an independent prognostic marker in chronic lymphocytic leukaemia.
Thu Mar 01 00:00:00 EST 2012
Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research
Tromp JM,Geest CR,Breij EC,Elias JA,van Laar J,Luijks DM,Kater AP,Beaumont T,van Oers MH,Eldering E
MHZAP7020 was used in Flow Cytometry to demonstrate that the Noxa-Mcl-1 balance determines sensitivity to ABT-737 in CD40-stimulated chronic lymphocytic leukemia cells.
Sun Jan 15 00:00:00 EST 2012
Quantitative analysis of protein phosphorylations and interactions by multi-colour IP-FCM as an input for kinetic modelling of signalling networks.
Deswal S,Schulze AK,Höfer T,Schamel WW
MHZAP7020 was used in Immunoprecipitation to develop a multi-colour immunoprecipitation technique for studying signal transduction events.
Tue Dec 06 00:00:00 EST 2011
Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1.
Huber S,Oelsner M,Decker T,zum Büschenfelde CM,Wagner M,Lutzny G,Kuhnt T,Schmidt B,Oostendorp RA,Peschel C,Ringshausen I
MHZAP7020 was used in flow cytometry to elucidate the mechanisms of sorafenib-induced cell death.
Sun May 01 00:00:00 EDT 2011
Cluster analysis of immunophenotypic data: the example of chronic lymphocytic leukemia.
Zucchetto A,Cattarossi I,Nanni P,Zaina E,Prato G,Gilestro M,Marconi D,Bulian P,Rossi FM,Del Vecchio L,Omedè P,Geuna M,Del Poeta G,Gattei V
MHZAP7020 was used in flow cytometry to identify the immunophenotypic signature of chronic lymphocytic leukemia subsets with different prognosis
Sun Jan 30 00:00:00 EST 2011
Prognostic impact of ZAP-70 expression in chronic lymphocytic leukemia: mean fluorescence intensity T/B ratio versus percentage of positive cells.
Journal of translational medicine
Rossi FM,Del Principe MI,Rossi D,Irno Consalvo M,Luciano F,Zucchetto A,Bulian P,Bomben R,Dal Bo M,Fangazio M,Benedetti D,Degan M,Gaidano G,Del Poeta G,Gattei V
MHZAP7020 was used in Flow cytometry/Cell sorting to assess the prognostic significance of detecting the percentage of ZAP-70 positive cells in chronic lymphocytic leukaemia by three different methods.
Mon Mar 08 00:00:00 EST 2010
High lymphoid enhancer-binding factor-1 expression is associated with disease progression and poor prognosis in chronic lymphocytic leukemia.
Erdfelder F,Hertweck M,Filipovich A,Uhrmacher S,Kreuzer KA
MHZAP7020 was used in flow cytometry to report that LEF1 expression is associated with poor prognosis and disease progression of chronic lymphocytic leukemia.
Tue Jan 26 00:00:00 EST 2010
ZAP-70 expression, as detected by immunohistochemistry on bone marrow biopsies from early-phase CLL patients, is a strong adverse prognostic factor.
Zanotti R,Ambrosetti A,Lestani M,Ghia P,Pattaro C,Remo A,Zanetti F,Stella S,Perbellini O,Prato G,Guida G,Caligaris-Cappio F,Menestrina F,Pizzolo G,Chilosi M
MHZAP7020 was used in Flow Cytometry to conclude detection of ZAP-70 on formalin-fixed BM biopsies at diagnosis appears a useful methodological approach to identify patients with poor prognosis in CLL.
Mon Jan 01 00:00:00 EST 2007
Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia.
Del Principe MI,Del Poeta G,Buccisano F,Maurillo L,Venditti A,Zucchetto A,Marini R,Niscola P,Consalvo MA,Mazzone C,Ottaviani L,Panetta P,Bruno A,Bomben R,Suppo G,Degan M,Gattei V,de Fabritiis P,Cantonetti M,Lo Coco F,Del Principe D,Amadori S
MHZAP7020 was used in Flow cytometry/Cell sorting to suggest that ZAP-70 protein improves the prognostic significance of cytogenetics and may be a better predictor than IgV(H) gene status.
Tue Aug 01 00:00:00 EDT 2006
ZAP-70 by flow cytometry: a comparison of different antibodies, anticoagulants, and methods of analysis.
Cytometry. Part B, Clinical cytometry
Best OG,Ibbotson RE,Parker AE,Davis ZA,Orchard JA,Oscier DG
MHZAP7020 was used in Flow cytometry/Cell sorting to support a rapid method for ZAP-70 measurement using commercially available fixation/permeabilization reagents, a conjugated antibody, and a ratiometric method of analysis that minimizes subjective interpretation of the results.
Sat Jul 15 00:00:00 EDT 2006
A scoring system based on the expression of six surface molecules allows the identification of three prognostic risk groups in B-cell chronic lymphocytic leukemia.
Journal of cellular physiology
Zucchetto A,Bomben R,Dal Bo M,Sonego P,Nanni P,Rupolo M,Bulian P,Dal Maso L,Del Poeta G,Del Principe MI,Degan M,Gattei V
MHZAP7020 was used in flow cytometry describe an immunophenotypic scoring system for B-cell chronic lymphocytic leukemia
Mon May 01 00:00:00 EDT 2006