This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
MA5-12624 targets ZAP-70 in IHC (P) and WB applications and shows reactivity with Human samples.
The MA5-12624 immunogen is gST-fusion to tandem SH2 domains of human ZAP-70 corresponding to residues 1-254.
Mutations in ZAP-70 gene results in a form of Severe Combined Immunodeficiency Syndrome (SCID) in humans. ZAP-70 expression also defines a subset of Chronic Lymphocytic Leukaemia (CLL) in patients with unmutated Ig gene and poor clinical course.
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Protein Aliases: 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; 70kD; Syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase; zeta-chain associated protein kinase, 70kD
Gene Aliases: ADMIO2; IMD48; SRK; STCD; STD; TZK; ZAP-70; ZAP70
UniProt ID: (Human) P43403
Entrez Gene ID: (Human) 7535