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Invitrogen
alpha Catenin Monoclonal Antibody (1G5)
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FIGURE: 1 / 12
alpha Catenin Antibody (MA1-2000) in ICC/IF
Immunofluorescent analysis of alpha Catenin using Catenin alpha Monoclonal Antibody (1G5) (Product # MA1-2000) shows staining in A2058 Cells. Catenin alpha (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with an antibody recognizing Catenin alpha (Pro... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-2000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G5
Immunogen
90 kDa MBP/alpha catenin fusion protein purified on amylose column.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-2000 detects alpha catenin from human samples.
MA1-2000 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~102 kDa protein representing alpha catenin from scc-1 cell extract. In Western blot, this antibody did not cross-react with mouse samples. MA1-2000 can also be used in immunoprecipitation and immunofluorescence procedures.
The MA1-2000 immunogen is a 90 kDa MBP/alpha catenin fusion protein purified via an amylose column.
Target Information
Alpha catenin is a member of the b-catenin family of cytosolic proteins. Alpha catenin interacts with N-cadherin and b-catenin on the cytosolic side of adherins junctions to mediate the interaction with the actin cytoskeleton. Alpha catenin is a homodimer in solution, but dissociates to form a 1:1 heterodimer with b-catenin in order to interact with cadherins. It also regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Alpha catenin also functions in the control of the startle modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-catenin; alpha-catenin-related protein; alpha-E-catenin; alpha-N-catenin; alphaE-catenin; alphaN-catenin; cadherin-associated protein; cadherin-associated protein, related; cancer/testis antigen 114; catenin; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin (cadherin-associated protein), alpha 2; Catenin alpha1; Catenin alpha2; Catenin-alpha1; Catenin-alpha2; epididymis secretory sperm binding protein; FLJ36832; FLJ52416; HGNC:2509; NY-REN-13 antigen; renal carcinoma antigen NY-REN-13; unnamed protein product
Gene Aliases: CAP-R; CAP102; CAPR; CDCBM9; CT114; CTNR; MDBS2; MDPT2
UniProt ID: (Human) P35221, (Human) P26232
Entrez Gene ID: (Human) 1495, (Human) 1496
ovarian follicle development
cell adhesion
male gonad development
gap junction assembly
cell migration
axon regeneration
odontogenesis of dentin-containing tooth
apical junction assembly
response to estrogen
cellular response to indole-3-methanol
cell-cell adhesion
negative regulation of protein localization to nucleus
cytoskeleton organization
axonogenesis
regulation of neuron projection development
radial glia guided migration of Purkinje cell
negative regulation of Arp2/3 complex-mediated actin nucleation
dendrite morphogenesis
brain morphogenesis
regulation of synapse structural plasticity
prepulse inhibition
modification of postsynaptic actin cytoskeleton
regulation of neuron migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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