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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the internal region of human SGCA|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex, which is localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. Four sarcoglycan subunit proteins, designated alpha-, beta-, gamma- and delta-sarcoglycan, form a complex on the skeletal muscle cell surface membrane. A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, which is observed in the autosomal recessive muscular dystrophy, sarcoglycanopathy. In smooth muscle, beta- and delta-sarcoglycans are associated with epsilon-sarcoglycan, a glycoprotein homologous to alpha-sarcoglycan. Additionally, a complete deficiency in delta-sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
50 kDa dystrophin-associated glycoprotein; 50DAG; 50kD DAG; adhalin; ADL; alpha-Sarcoglycan; alpha-SG; DAG2; Dystroglycan 2; dystroglycan-2; Dystroglycan2; limb girdle muscular dystrophy 2D; Sarcoglycan alpha; sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); SG alpha; SG-alpha; SGCA
50DAG; adhalin; ADL; Asg; DAG2; DMDA2; LGMD2D; SCARMD1; SGCA