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|Tested species reactivity||Human|
|Published species reactivity||Rat, Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant human alpha-synuclein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||1-3 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Alpha-Synuclein belongs to the Synuclein family, which also includes beta and gamma Synuclein, and is predominantly expressed in neurons, concentrated at synaptic terminals. Synucleins may be involved in the regulation of dopamine release and transport and the modulation of synaptic vesicle function. Alpha-Synuclein is a small, presynaptic protein that is the major nonamyloid component of the pathological inclusions characteristic of a wide range of neurodegenerative disorders, collectively known as synucleinopathies. It is involved in the formation of SNARE complexes. Most significantly, aggregated Alpha-Synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders. Mutation of the alpha-synuclein gene is associated with familial forms of PD. Alpha-Synuclein is known to reduce the fibrillization of the microtubule-associated protein, tau, to bind various targets such as 14-3-3, protein kinase C, synphilin-1, Elk and Tat-binding protein 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons.
32-8100 was used in immunohistochemistry - frozen section to determine if glucose-regulated protein 78 contributes to the development of Parkinson's disease.
|Salganik M,Sergeyev VG,Shinde V,Meyers CA,Gorbatyuk MS,Lin JH,Zolotukhin S,Gorbatyuk OS||Neurobiology of aging (36:2213)||2015|
||Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons.||Taschenberger G,Garrido M,Tereshchenko Y,Bähr M,Zweckstetter M,Kügler S||Acta neuropathologica (123:671)||2012|
|Human||Not Cited||Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line.||Lotharius J,Barg S,Wiekop P,Lundberg C,Raymon HK,Brundin P||The Journal of biological chemistry (277:38884)||2002|
|Rat||Not Cited||Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons.||Taschenberger G,Garrido M,Tereshchenko Y,Bähr M,Zweckstetter M,Kügler S||Acta neuropathologica (123:671)||2012|
|Fine epitope mapping of monoclonal antibodies specific to human alpha-synuclein.||Choi JY,Park HJ,Seong YM,Choi EY,Min BR,Rhim H||Neuroscience letters (397:53)||2006|
|Human||Not Cited||An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.||Sherer TB,Betarbet R,Stout AK,Lund S,Baptista M,Panov AV,Cookson MR,Greenamyre JT||The Journal of neuroscience : the official journal of the Society for Neuroscience (22:7006)||2002|
alpha; alpha-synuclein; NACP; non A-beta component of AD amyloid; SYN; synuclein; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor); SYUA
NACP; PARK1; PARK4; PD1; SNCA