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|Tested species reactivity||Human|
|Published species reactivity||Rat, Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant human alpha-synuclein|
|Storage buffer||PBS, pH 7.2, with 0.1% BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
|Western Blot (WB)||0.5-1.0 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control for this product is SHSY-5Y cells. It will not cross-react with mouse or rat.
Alpha-Synuclein belongs to the Synuclein family, which also includes beta and gamma Synuclein, and is predominantly expressed in neurons, concentrated at synaptic terminals. Synucleins may be involved in the regulation of dopamine release and transport and the modulation of synaptic vesicle function. Alpha-Synuclein is a small, presynaptic protein that is the major nonamyloid component of the pathological inclusions characteristic of a wide range of neurodegenerative disorders, collectively known as synucleinopathies. It is involved in the formation of SNARE complexes. Most significantly, aggregated Alpha-Synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders. Mutation of the alpha-synuclein gene is associated with familial forms of PD. Alpha-Synuclein is known to reduce the fibrillization of the microtubule-associated protein, tau, to bind various targets such as 14-3-3, protein kinase C, synphilin-1, Elk and Tat-binding protein 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy.
MA1-12874 was used in immunohistochemistry to study multiple system atrophy and the role of alpha-synuclein in delaying oligodendrocyte progenitor maturation
|May VE,Ettle B,Poehler AM,Nuber S,Ubhi K,Rockenstein E,Winner B,Wegner M,Masliah E,Winkler J||Neurobiology of aging (35:2357)||2014|
Alpha-synuclein transfers from neurons to oligodendrocytes.
MA1-12874 was used in immunohistochemistry to study the alpha-synuclein transfers from neurons to oligodendrocytes
|Reyes JF,Rey NL,Bousset L,Melki R,Brundin P,Angot E||Glia (62:387)||2014|
A reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3.
MA1-12874 was used in immunohistochemistry to re-evaluate the neuropathology of frontotemporal dementia linked to chromosome 3 in a Danish family
|Holm IE,Englund E,Mackenzie IR,Johannsen P,Isaacs AM||Journal of neuropathology and experimental neurology (66:884)||2007|
Differential expression of alpha-synuclein in hippocampal neurons.
MA1-12874 was used in immunocytochemistry to study the hippocampal neuronal expression of alpha-synuclein under normal and pathological conditions
|Taguchi K,Watanabe Y,Tsujimura A,Tatebe H,Miyata S,Tokuda T,Mizuno T,Tanaka M||PloS one (9:null)||2014|
α-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity.
MA1-12874 was used in western blot to study the role of Rab3a and synaptic activity in the membrane association of alpha-synuclein
|Chen RH,Wislet-Gendebien S,Samuel F,Visanji NP,Zhang G,Marsilio D,Langman T,Fraser PE,Tandon A||The Journal of biological chemistry (288:7438)||2013|
α-synuclein phosphorylation and truncation are normal events in the adult human brain.
MA1-12874 was used in western blot to study the constitutive truncation and phosphorylation of alpha-synuclein in normal human brain
|Muntané G,Ferrer I,Martinez-Vicente M||Neuroscience (200:106)||2012|
Abnormal alpha-synuclein solubility, aggregation and nitration in the frontal cortex in Pick's disease.
MA1-12874 was used in western blot to study the distinct changes in the solubility, aggregation and tyrosine nitration of alpha-synuclein observed in the frontal cortex in Pick' disease
|Dalfó E,Martinez A,Muntané G,Ferrer I||Neuroscience letters (400:125)||2006|
non A-beta component of AD amyloid; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor)
NACP; PARK1; PARK4; PD1; SNCA