Proteintech

alpha Tubulin Monoclonal Antibody (1E4C11)

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alpha Tubulin Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 66031-1-IG (alpha Tubulin antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IGG (H+L).

alpha Tubulin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 66031-1-IG ( alpha Tubulin antibody at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

alpha Tubulin Antibody in Western Blot (WB) — SW 1990 cells were subjected to SDS PAGE followed by western blot with 66031-1-Ig (alpha Tubulin antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours.

alpha Tubulin Antibody in Flow Cytometry (Flow) — 1X10^6 HeLa cells were stained with 0.2ug alpha Tubulin antibody (66031-1-IG, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). FITC-Goat anti-Mouse IGG with dilution 1:100.

alpha Tubulin Antibody in Immunoprecipitation (IP) — IP result of anti-alpha Tubulin (IP:66031-1-IG, 5ug; Detection:66031-1-IG 1:1000) with HeLa cells lysate 2800ug.

Product Details

66031-1-IG

Applications	Tested Dilution	Publications
Western Blot (WB)	1:2,000-1:10,000	View 79 publications 79 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:500	-
Immunocytochemistry (ICC/IF)	1:50-1:500	View 10 publications 10 publications
Flow Cytometry (Flow)	0.2 µg/1x10^6 cells	-
Immunoprecipitation (IP)	0.5-4.0 µg	-
Miscellaneous PubMed (Misc)	-	View 16 publications 16 publications

Product Specifications
Species Reactivity	Dog, Human, Mouse, Rat
Published species	Human, Insect, Mouse, Plant, Rat
Host/Isotype	Mouse / IgG2b
Class	Monoclonal
Type	Antibody
Clone	1E4C11
Immunogen	alpha Tubulin Fusion Protein Ag18034 (1-451 aa encoded by BC009314)
Conjugate	Unconjugated CoraLite488 CoraLite594 HRP
Form	Liquid
Concentration	1.73 mg/mL
Purification	Protein A
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

This antibody specifically recognizes Tubulin Alpha.

Immunogen sequence: MRECISIHV GQAGVQIGNA CWELYCLEHG IQPDGQMPSD KTIGGGDDSF NTFFSETGAG KHVPRAVFVD LEPTVIDEVR TGTYRQLFHP EQLITGKEDA ANNYARGHYT IGKEIIDLVL DRIRKLADQC TGLQGFLVFH SFGGGTGSGF TSLLMERLSV DYGKKSKLEF SIYPAPQVST AVVEPYNSIL TTHTTLEHSD CAFMVDNEAI YDICRRNLDI ERPTYTNLNR LISQIVSSIT ASLRFDGALN VDLTEFQTNL VPYPRIHFPL ATYAPVISAE KAYHEQLSVA EITNACFEPA NQMVKCDPRH GKYMACCLLY RGDVVPKDVN AAIATIKTKR SIQFVDWCPT GFKVGINYQP PTVVPGGDLA KVQRAVCMLS NTTAIAEAWA RLDHKFDLMY AKRAFVHWYV GEGMEEGEFS EAREDMAALE KDYEEVGVDS VEGEGEEEGE EY (1-451 aa encoded by BC009314)

Target Information

Alpha Tubulin is a part of a heterodimer consisting of alpha and beta tubulin subunits. The alpha and beta tubulins, which are each about 55 kDa MW, are homologous but not identical. Alpha-beta tubulin heterodimer is the basic building block of microtubules, and this intracellular cylindrical filamentous structure is present in almost eukaryotic cells. Microtubules serve as structural supports and lines of transport within the cell, as well as serving a key role in mitosis. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. The gene that encodes alpha tubulin is highly similar to the mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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El Najjar F,Cifuentes-Muñoz N,Chen J,Zhu H,Buchholz UJ,Moncman CL,Dutch RE

Thu Sep 01 00:00:00 EDT 2016

A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

Tsai MH,Kuo PW,Myers CT,Li SW,Lin WC,Fu TY,Chang HY,Mefford HC,Chang YC,Tsai JW

Thu Sep 01 00:00:00 EDT 2016

Disrupted-in-schizophrenia 1 (DISC1) and Syntaphilin collaborate to modulate axonal mitochondrial anchoring.

Molecular brain

Park C,Lee SA,Hong JH,Suh Y,Park SJ,Suh BK,Woo Y,Choi J,Huh JW,Kim YM,Park SK

Sat Jul 02 00:00:00 EDT 2016

Small-Activating RNA Can Change Nucleosome Positioning in Human Fibroblasts.

Journal of biomolecular screening

Wang B,Sun J,Shi J,Guo Q,Tong X,Zhang J,Hu N,Hu Y

Fri Jul 01 00:00:00 EDT 2016

Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.

PLoS pathogens

Ren Y,Zhao P,Liu J,Yuan Y,Cheng Q,Zuo Y,Qian L,Liu C,Guo T,Zhang L,Wang X,Qian G,Li L,Ge J,Dai J,Xiong S,Zheng H

Fri Jul 01 00:00:00 EDT 2016

Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5.

Biochemical and biophysical research communications

Qian G,Ren Y,Zuo Y,Yuan Y,Zhao P,Wang X,Cheng Q,Liu J,Zhang L,Guo T,Liu C,Zheng H

Fri Jun 03 00:00:00 EDT 2016

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.

Nature chemical biology

Theodoropoulos PC,Gonzales SS,Winterton SE,Rodriguez-Navas C,McKnight JS,Morlock LK,Hanson JM,Cross B,Owen AE,Duan Y,Moreno JR,Lemoff A,Mirzaei H,Posner BA,Williams NS,Ready JM,Nijhawan D

Fri Apr 01 00:00:00 EDT 2016

Influence of miR-30b regulating humoral immune response by genetic difference.

Immunologic research

Duan ZQ,Shi JD,Wu MN,Hu NZ,Hu YZ

Mon Feb 01 00:00:00 EST 2016

Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway.

Acta pharmacologica Sinica

Kong YL,Shen Y,Ni J,Shao DC,Miao NJ,Xu JL,Zhou L,Xue H,Zhang W,Wang XX,Lu LM

Mon Feb 01 00:00:00 EST 2016

Drosophila Dicer-2 has an RNA interference-independent function that modulates Toll immune signaling.

Science advances

Wang Z,Wu D,Liu Y,Xia X,Gong W,Qiu Y,Yang J,Zheng Y,Li J,Wang YF,Xiang Y,Hu Y,Zhou X

Thu Oct 01 00:00:00 EDT 2015

SUMOylation at K707 of DGCR8 controls direct function of primary microRNA.

Nucleic acids research

Zhu C,Chen C,Huang J,Zhang H,Zhao X,Deng R,Dou J,Jin H,Chen R,Xu M,Chen Q,Wang Y,Yu J

Fri Sep 18 00:00:00 EDT 2015

SUMOylation at K707 of DGCR8 controls direct function of primary microRNA.

Nucleic acids research

Zhu C,Chen C,Huang J,Zhang H,Zhao X,Deng R,Dou J,Jin H,Chen R,Xu M,Chen Q,Wang Y,Yu J

Fri Sep 18 00:00:00 EDT 2015

Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria.

Journal of proteome research

Yang L,Lian X,Zhang W,Guo J,Wang Q,Li Y,Chen Y,Yin X,Yang P,Lan F,He QY,Zhang G,Wang T

Fri Sep 04 00:00:00 EDT 2015

Analysis of grayscale characteristics in images of labeled microtubules from cultured cardiac myocytes.

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

Dang Y,Lan X,Zhang Q,Li L,Huang Y

Wed Apr 01 00:00:00 EDT 2015

Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment.

Journal of virology

Xie M,Xuan B,Shan J,Pan D,Sun Y,Shan Z,Zhang J,Yu D,Li B,Qian Z

Sun Mar 01 00:00:00 EST 2015

Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats.

Molecular and cellular endocrinology

Li D,Wang X,Lan X,Li Y,Liu L,Yi J,Li J,Sun Q,Wang Y,Li H,Zhong N,Holmdahl R,Lu S

Sun Feb 15 00:00:00 EST 2015

Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.

Journal of molecular histology

Lu M,Wu J,He F,Wang XL,Li C,Chen ZN,Bian H

Sun Feb 01 00:00:00 EST 2015

Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates.

Neurobiology of aging

Luccarini I,Grossi C,Rigacci S,Coppi E,Pugliese AM,Pantano D,la Marca G,Ed Dami T,Berti A,Stefani M,Casamenti F

Sun Feb 01 00:00:00 EST 2015

Increased stathmin expression strengthens fear conditioning in epileptic rats.

Biomedical reports

Zhang L,Feng D,Tao H,DE X,Chang Q,Hu Q

Thu Jan 01 00:00:00 EST 2015

Modulation of amylose content by structure-based modification of OsGBSS1 activity in rice (Oryza sativa L.).

Plant biotechnology journal

Liu D,Wang W,Cai X

Mon Dec 01 00:00:00 EST 2014

TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer.

Oncotarget

Li X,Liu Y,Chen W,Fang Y,Xu H,Zhu HH,Chu M,Li W,Zhuang G,Gao WQ

Wed Oct 15 00:00:00 EDT 2014

lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI.

The FEBS journal

Zhu M,Chen Q,Liu X,Sun Q,Zhao X,Deng R,Wang Y,Huang J,Xu M,Yan J,Yu J

Fri Aug 01 00:00:00 EDT 2014

Axl receptor tyrosine kinase expression in breast cancer.

Journal of clinical pathology

D'Alfonso TM,Hannah J,Chen Z,Liu Y,Zhou P,Shin SJ

Fri Aug 01 00:00:00 EDT 2014

INMAP, a novel truncated version of POLR3B, represses AP-1 and p53 transcriptional activity.

Molecular and cellular biochemistry

Yunlei Z,Zhe C,Yan L,Pengcheng W,Yanbo Z,Le S,Qianjin L

Fri Feb 01 00:00:00 EST 2013

Bioinformatics

Protein Aliases: alpha tubulin; alpha-tubulin; Alpha-tubulin 1; Alpha-tubulin 2; Alpha-tubulin 3; Alpha-tubulin 3C; alpha-tubulin 3C/D; Alpha-tubulin 3E; Alpha-tubulin 4; Alpha-tubulin 6; Alpha-tubulin isotype M-alpha-1; Alpha-tubulin isotype M-alpha-2; Alpha-tubulin isotype M-alpha-4; Alpha-tubulin isotype M-alpha-6; Alpha-tubulin ubiquitous; Detyrosinated tubulin alpha-1A chain; Detyrosinated tubulin alpha-1B chain; Detyrosinated tubulin alpha-1C chain; Detyrosinated tubulin alpha-3C chain; Detyrosinated tubulin alpha-3E chain; FLJ30169; H2 ALPHA; hum-a-tub1; hum-a-tub2; Talpha1 alpha-tubulin; Testis-specific alpha-tubulin; TUBA1/3/4; Tubulin alpha; Tubulin alpha-1 chain; Tubulin alpha-1A chain; Tubulin alpha-1B chain; Tubulin alpha-1C chain; Tubulin alpha-2 chain; Tubulin alpha-3 chain; Tubulin alpha-3C chain; Tubulin alpha-3E chain; Tubulin alpha-4 chain; Tubulin alpha-4A chain; Tubulin alpha-6 chain; Tubulin alpha-ubiquitous chain; Tubulin B-alpha-1; Tubulin H2-alpha; Tubulin K-alpha-1; tubulin, alpha 1; tubulin, alpha 1 (testis specific); tubulin, alpha 1a; tubulin, alpha 1b; tubulin, alpha 1c; tubulin, alpha 2; tubulin, alpha 3c; tubulin, alpha 3e; tubulin, alpha 4; tubulin, alpha 4a; tubulin, alpha 6; tubulin, alpha, brain-specific; tubulin, alpha, ubiquitous

Gene Aliases: ALS22; B-ALPHA-1; bA408E5.3; bcm948; H2-ALPHA; K-ALPHA-1; LIS3; M[a]4; M[a]6; RGD1565476; Tuba-1; TUBA1; TUBA1A; TUBA1B; TUBA1C; TUBA2; TUBA3; TUBA3C; TUBA3E; Tuba4; TUBA4A; TUBA6

UniProt ID: (Human) Q71U36, (Human) P68363, (Human) Q9BQE3, (Human) P0DPH7, (Human) Q6PEY2, (Human) P68366, (Mouse) P68369, (Rat) P68370, (Mouse) P05213, (Rat) Q6P9V9, (Mouse) P68373, (Rat) Q6AYZ1, (Mouse) P68368, (Rat) Q5XIF6