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Human Caco-2 cells stained with Mouse anti-a-Tubulin – Alexa Fluor® 488 Cat.No. 322588) showing cytoskeleton, and mitotic spindle. The DNA is counter stained with blue Hoechst 33258 (Cat. No H3569) stain, and actin is stained with Alexa Fluor® 568 Phalloidin (Cat. No A12380).
|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Sarkosyl-resistant filament from sea urchin sperm axonemes|
|Conjugate||Alexa Fluor® 488|
|Storage buffer||PBS, pH 7.4, with 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||2.5-5 µg/ml|
|Immunofluorescence (IF)||2.5-5 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
alpha 1; Alpha-tubulin 1; Alpha-tubulin 3; Alpha-tubulin isotype M-alpha-1; H2-ALPHA; hum-a-tub1; hum-a-tub2; Talpha1 alpha-tubulin; TUBA1; tubulin; Tubulin alpha-1 chain; Tubulin alpha-1A chain; Tubulin alpha-3 chain; tubulin alpha-4A chain; Tubulin B-alpha-1; tubulin H2-alpha; tubulin, alpha 1; tubulin, alpha 1a; tubulin, alpha, brain-specific
B-ALPHA-1; LIS3; Tuba-1; Tuba1; TUBA1A; TUBA3