The Band 3 protein is the most abundant integral protein of human erythrocyte membranes and functions as the major anion transporter polypeptide of erythrocytes. Band 3 is a 90-100 kDa protein, its microheterogeneity is ascribed mainly to the structural heterogeneity of the carbohydrate moiety. The C-terminal portion of the molecule spans the membrane several times, and is responsible for anion transport. The N-terminal portion, comprising almost half of the polypeptide chain of Band 3, is located inside the red cell and interacts with cytoskeletal and cytoplasmic proteins such as ankyrin.
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Protein Aliases: AE 1; Anion exchange protein 1; anion exchanger 1; anion exchanger-1; Band 3 anion transport protein; C13orf8; CAMP; CD233; CHAMP; Diego blood group; erythrocyte membrane protein band 3; erythroid anion exchange protein; Froese blood group; MEB3; MGC116750; MGC116753; MGC126619; MGC126623; solute carrier family 4 (anion exchanger), member 1 (Diego blood group); Solute carrier family 4 member 1; solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); solute carrier family 4, anion exchanger, number 1; Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3); Swann blood group; Waldner blood group; Wright blood group; ZNF828
Gene Aliases: AE1; BND3; CD233; CHC; DI; EMPB3; EPB3; FR; l11Jus51; RTA1A; SAO; SLC4A1; SPH4; SW; WD; WD1; WR