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Alomone Labs, LTD

beta 2-Adrenergic Receptor (extracellular) Polyclonal Antibody

View all (58) beta-2 Adrenergic Receptor antibodies

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beta 2-Adrenergic Receptor (extracellular) Polyclonal Antibody

Product Details

AAR-016-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-

Flow Cytometry (Flow)

2.5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)NGSRAPDHDVTQERDE, corresponding to amino acid residues 15-30 of mouse ADRB2, Extracellular, N-terminus
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.7 mg/mL

Amount

140 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Adrenergic beta 2- receptor surface; adrenergic receptor, beta 2; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; adrenoceptor beta 2, surface; AR beta2; beta 2-AR; beta-2 adrenoceptor; beta-2 adrenoreceptor; beta-adrenergic receptor; beta2-Adrenoreceptor; catecholamine receptor; HGNC:286; putative; unnamed protein product

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Gene Aliases: Adrb-2; ADRB2R; ADRBR; ARB2; B2AR; Badm; BAR; BETA2AR; Gpcr7

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UniProt ID: (Human) P07550, (Mouse) P18762

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Entrez Gene ID: (Human) 154, (Mouse) 11555, (Rat) 24176

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Function(s)
beta-amyloid binding G-protein coupled receptor activity adrenergic receptor activity beta-adrenergic receptor activity beta2-adrenergic receptor activity protein binding adenylate cyclase binding potassium channel regulator activity enzyme binding identical protein binding protein homodimerization activity macromolecular complex binding norepinephrine binding G-protein alpha-subunit binding B2 bradykinin receptor binding ionotropic glutamate receptor binding protein phosphatase 2A binding receptor-receptor interaction PDZ domain binding epinephrine binding
Process(es)
regulation of systemic arterial blood pressure by norepinephrine-epinephrine diet induced thermogenesis vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure regulation of sodium ion transport diaphragm contraction positive regulation of the force of heart contraction by epinephrine receptor-mediated endocytosis regulation of smooth muscle contraction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway regulation of heart contraction positive regulation of cell proliferation associative learning response to cold positive regulation of cardiac muscle cell apoptotic process negative regulation of cardiac muscle cell apoptotic process positive regulation of sodium ion transport negative regulation of angiogenesis negative regulation of ossification positive regulation of bone mineralization heat generation positive regulation of ATPase activity synaptic transmission, glutamatergic negative regulation of urine volume negative regulation of multicellular organism growth vasodilation positive regulation of apoptotic process positive regulation of potassium ion transport positive regulation of MAPK cascade bone resorption negative regulation of G-protein coupled receptor protein signaling pathway positive regulation of transcription from RNA polymerase II promoter negative regulation of smooth muscle contraction positive regulation of skeletal muscle tissue growth brown fat cell differentiation regulation of calcium ion transport excitatory postsynaptic potential positive regulation of mini excitatory postsynaptic potential cellular response to hypoxia response to catecholamine adrenergic receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-inhibiting adrenergic receptor signaling pathway regulation of blood vessel diameter AMPA selective glutamate receptor signaling pathway presynaptic modulation of chemical synaptic transmission positive regulation of cardiac muscle cell contraction positive regulation of cold-induced thermogenesis positive regulation of cAMP/PKA signal transduction positive regulation of glutamate receptor signaling pathway positive regulation of autophagosome maturation positive regulation of lipophagy cellular response to beta-amyloid positive regulation of calcium ion import across plasma membrane cell surface receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway endosome to lysosome transport response to psychosocial stress response to hypoxia liver development positive regulation of the force of heart contraction by epinephrine-norepinephrine female pregnancy response to progesterone response to testosterone response to estrogen estrous cycle positive regulation of developmental growth negative regulation of multicellular organismal process response to dexamethasone response to monoamine liver regeneration
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