This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated. View Details
MA1-118 was successfully used to detect E18 Sparague Dawley primary cortical neurons.
MA1-118 can be used for immunofluorescence analysis of beta III tubulin in the ectoderm derived from human embryonic stem cells.
Western blot analysis of MA1-118 detects an ~50 kDa protein in neuronal-type cells. In bovine, a unknown band at ~32 kDa is also detected. MA1-118 shows specificity to beta-3 Tubulin and is non-reactive to lysates from non-neuronal cell types (e.g. HeLa cell lysate).
The betaIII-tubulin isoform is present dominantly in cells of neuronal origin and it is one of the earliest markers of neuronal differentiation. It is regarded as a specific probe for the cells of neuronal origin as well as for the tumours originating from these cells. The betaIII-tubulin is most abundant in cells of neuronal origin, but was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: beta tubulin 3; betaIII-tubulin; class III beta-tubulin; MC1R; melanocortin receptor 1; Neuron-specific class III beta-tubulin; TUBB; tubulin beta; Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin beta-III; tubulin, beta 3 class III; tubulin, beta, 3; tubulin, beta, 4
Gene Aliases: 3200002H15Rik; beta-4; CDCBM; CDCBM1; CFEOM3; CFEOM3A; FEOM3; I79_000194; M(beta)3; M(beta)6; mc1R; TUBB3; TUBB4
Molecular Function: tubulin