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|Tested species reactivity||Avian, Chicken, Mammals|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant full length protein (Chicken).|
|Storage buffer||PBS, pH 7.4, with 1% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-34999 detects beta Catenin from avian, chicken, mammal samples.
MA1-34999 has been successfully used in immunofluorescence applications.
The MA1-34999 immunogen is: Recombinant full length protein (Chicken).
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
IP-MS enrichment of CTNNB1 (LFQ intensity): CTNNB1 was enriched 27-fold from HCT116 lysate compared to background proteins, using the optimized IP-MS workflow with Pierce MS-Compatible Magnetic IP Kit protein A/G (Part No. 90409) and CTNNB1 antibody (Part No. MA1-34999). The STRING database (www.string-db.org) was used to identify the protein interactor list. See more information on IP-MS verification of antibody selectivity. IP-MS validation info.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
beta catenin; beta-catenin; catenin (cadherin associated protein), beta 1, 88kDa; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta; catenin beta-1; CTNNB; DKFZp686D02253; FLJ25606; FLJ37923
armadillo; beta-catenin; Bfc; BOS_20731; Catnb; CHBCAT; CTNNB; CTNNB1; Mesc; MRD19; OK/SW-cl.35; PRO2286