Invitrogen
Antibody target was verified by IP Mass Spectrometry to ensure the antibody binds to the antigen stated. View details.
Catalog #:71-2700
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| TESTED APPLICATIONS | DILUTION |
|---|---|
| ELISA (ELISA) | Assay Dependent |
| Immunocytochemistry (ICC) | Assay Dependent |
| Immunofluorescence (IF) | Assay Dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20-1:200 |
| Immunoprecipitation (IP) | Assay Dependent |
| PUBLISHED APPLICATIONS | |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | See 2 publications below |
| Immunocytochemistry (ICC) | See 6 publications below |
| Western Blot (WB) | See 10 publications below |
| Immunoprecipitation (IP) | See 2 publications below |
| Miscellaneous PubMed (MISC) | See 5 publications below |
| Immunohistochemistry (IHC) | See 2 publications below |
| Immunofluorescence (IF) | See 1 publications below |
| ChIP assay (ChIP) | See 1 publications below |
| Immunohistochemistry (Frozen) (IHC (F)) | See 5 publications below |
| Tested Species reactivity | Chicken, Human, Mouse, Rat, Xenopus |
| Published species reactivity | Dog , Rat , Pig , Human , Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid synthetic peptide derived from the C-terminus of the human/ mouse beta-catenin protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/ml |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage conditions | -20°C |
| RRID | AB_2533982 |
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: beta; beta catenin; Beta-catenin; catenin; catenin (cadherin associated protein), beta 1, 88kDa; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta; Catenin beta-1; CATNB; CTNB1; CTNNB
Gene Aliases: armadillo; beta-catenin; Bfc; Catnb; CHBCAT; CTNNB; CTNNB1; Mesc; MRD19; OK/SW-cl.35; PRO2286
UniProt ID: (Human) P35222, (Mouse) Q02248, (Rat) Q9WU82
Entrez Gene ID: (Human) 1499, (Chicken) 395964, (Mouse) 12387, (Rat) 84353, (Xenopus) 399274
Molecular Function:
cell adhesion molecule
cytoskeletal protein
signaling molecule
storage protein
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