The Betatrophin protein, also known as the hepatocellular carcinoma-associated protein TD26, is an adipocyte- and liver-enriched insulin targeted gene that is thought to play a role in lipid metabolism be regulating serum triglyceride levels. Betatrophin is closely related to the angiopoietin-like (ANGPTL) protein family. Betatrophin mRNA increases in the cold environment and after treatment with a high-fat diet, while its mRNA levels decrease in response to fasting, suggesting that it may play a role in mediating thermogenesis and energy homeostasis.
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Protein Aliases: angiopoietin-like 8; Angiopoietin-like protein 8; ANGPTL8; Betatrophin; betatrophin variant 1; betatrophin variant 2; hepatocellular carcinoma-associated gene TD26; hepatocellular carcinoma-associated protein TD26; Lipasin; PRO1185; PVPA599; Refeeding-induced fat and liver protein; RIFL; TD26; UNQ599/PRO1185
Gene Aliases: ANGPTL8; C19orf80; PRO1185; PVPA599; RIFL; TD26; UNQ599/PRO1185
UniProt ID: (Human) Q6UXH0
Entrez Gene ID: (Human) 55908