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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 700-800 of an internal portion of human c-ABL. [Swiss-Prot# P00519]|
|Purification||Antigen affinity chromatography|
|Storage buffer||citric acid, pH 7-8|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Western Blot (WB)||2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Suggested positive control: antigen standard for ABL1 (transient overexpression lysate), K562 whole cell lysate.
c-ABL regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. It localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Activity of the c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. c-ABL also potentially regulates DNA repair by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Abelson murine leukemia oncogene; Abelson Murine Leukemia Viral Oncogene Homolog 1; Abelson murine leukemia viral v abl oncogene homolog 1; Abelson tyrosine-protein kinase 1; Abl 1 antib; bcr/c-abl oncogene protein; c-abl oncogene 1, receptor tyrosine kinase; p150; proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene homolog 1
ABL; ABL1; AI325092; bcr/abl; c-ABL; c-ABL1; E430008G22Rik; JTK7; p150; v-abl