|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Immunoprecipitation (IP)||Assay dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues A(71) M N E F S T L P L P N L R V V(86) C of the ligand binding domain of human c-erbB-3/HER-3 oncoprotein.|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||<0.1% sodium azide|
|Storage conditions||4° C, do not freeze|
PA1-30497 detects c-ErbB3 from human samples.
PA1-30497 has been successfully used in immunoprecipitation and immunohistochemistry (paraffin tissue) applications.
The PA1-30497 immunogen is: Synthetic peptide corresponding to residues A(71) M N E F S T L P L P N L R V V(86) C of the ligand binding domain of human c-erbB-3/HER-3 oncoprotein.
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c-erbB-3; c-erbB3; ErbB-3; erbB3-S; HER3; human epidermal growth factor receptor 3; LCCS2; MDA-BF-1; MGC88033; p180-ErbB3; p45-sErbB3; p85-sErbB3; Proto-oncogene-like protein c-ErbB-3; Receptor tyrosine-protein kinase erbB-3; Tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Gene Aliases: c-erbB-3; c-erbB3; ErbB-3; ERBB3; erbB3-S; HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3
UniProt ID: (Human) P21860
Entrez Gene ID: (Human) 2065
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