MA5-17076 targets FOS in FACS, IHC, pep-ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17076 immunogen is purified recombinant fragment of human FOS expressed in E. Coli.
MA5-17076 detects FOS which has a predicted molecular weight of approximately 40.7kDa.
FBJ murine osteosarcoma viral oncogene homolog is commonly known as Cellular protooncogene Fos (c-Fos). It belongs to the fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14. c-Fos heterodimerizes with c-Jun to form the Activator Protein -1 (AP-1) transcription factor which regulates transcription of several genes that play an important role in cellular signal transduction, cell proliferation and differentiation. c-Fos has been shown to be phosphorylated by various stimuli including growth factors and insulin at atleast seven different sites. The best known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK which regulates localization of c-Fos to the nucleus and is thus important for c-Fos induced transcriptional activity.
Protein Aliases: activator protein 1; cellular oncogene c-fos; Cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; Fos proto-oncogene, AP-1 trancription factor subunit; G0/G1 switch regulatory protein 7; Proto-oncogene c-Fos
Gene Aliases: AP-1; C-FOS; FOS; G0S7; p55
UniProt ID: (Human) P01100
Entrez Gene ID: (Human) 2353
Molecular Function: basic leucine zipper transcription factor