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Invitrogen
c-Jun Monoclonal Antibody (5B1)
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
Product Details
MA5-15881
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Published species
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5B1
Immunogen
Purified recombinant fragment of human c-Jun expressed in E. Coli.
Conjugate
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_11153582
Product Specific Information
MA5-15881 targets c-Jun in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human, mouse, and Non-human primate samples.
The MA5-15881 immunogen is purified recombinant fragment of human c-Jun expressed in E. Coli. .
MA5-15881 detects c-Jun which has a predicted molecular weight of approximately 43kDa.
Target Information
c-Jun is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Activator protein 1; AH119; AP1; cjun; enhancer-binding protein AP1; immediate early; Jun A; Jun activation domain binding protein; Jun oncogene; jun proto-oncogene; JUND; p39; Proto-oncogene c-Jun; transcription factor AP-1; Transcription factor AP-1 subunit Jun; Transcription factor Jun; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog
Gene Aliases: AP-1; AP1; c-Jun; JUN; Junc
UniProt ID: (Human) P05412, (Mouse) P05627
Entrez Gene ID: (Human) 3725, (Mouse) 16476
Molecular Function:
basic leucine zipper transcription factor
angiogenesis
microglial cell activation
release of cytochrome c from mitochondria
liver development
positive regulation of endothelial cell proliferation
outflow tract morphogenesis
transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
SMAD protein import into nucleus
Ras protein signal transduction
aging
learning
circadian rhythm
negative regulation of cell proliferation
response to radiation
response to mechanical stimulus
positive regulation of epithelial cell migration
regulation of cell death
monocyte differentiation
axon regeneration
negative regulation of protein autophosphorylation
response to lipopolysaccharide
cellular response to hormone stimulus
response to cytokine
leading edge cell differentiation
response to muscle stretch
Fc-epsilon receptor signaling pathway
regulation of cell proliferation
response to drug
response to hydrogen peroxide
negative regulation of DNA binding
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
positive regulation of GTPase activity
negative regulation by host of viral transcription
positive regulation by host of viral transcription
positive regulation of cell differentiation
positive regulation of monocyte differentiation
positive regulation of DNA replication
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
positive regulation of smooth muscle cell proliferation
regulation of sequence-specific DNA binding transcription factor activity
cellular response to potassium ion starvation
response to cAMP
regulation of cell cycle
membrane depolarization
SMAD protein signal transduction
eyelid development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
cellular response to calcium ion
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
positive regulation of DNA-templated transcription, initiation
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
positive regulation of cell proliferation
cellular process
positive regulation of apoptotic process
negative regulation of apoptotic process
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
transcriptional activator activity, RNA polymerase II transcription factor binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
GTPase activator activity
protein binding
transcription factor binding
enzyme binding
cAMP response element binding
identical protein binding
protein homodimerization activity
transcription regulatory region DNA binding
poly(A) RNA binding
protein heterodimerization activity
R-SMAD binding
HMG box domain binding
double-stranded DNA binding
sequence-specific DNA binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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